Pair Name	Ursolic acid, Doxorubicin
Disease Info	[ICD-11: 2C60]	Breast cancer		Investigative
Biological Phenomena	Induction-->Blockade of cell cycle in G0/G1 phase
Gene Regulation	Down-regulation	Phosphorylation	MTOR	hsa2475
	Down-regulation	Expression	PPARGC1A	hsa10891
	Up-regulation	Phosphorylation	PRKAA1	hsa5562
	Up-regulation	Expression	ROS1	hsa6098
	Down-regulation	Expression	SLC2A1	hsa6513
In Vitro Model	NCI-ADR-RES	High grade ovarian serous adenocarcinoma	Homo sapiens (Human)	CVCL_1452
Result	Ursolic acid augments the chemosensitivity of drug-resistant breast cancer cells to doxorubicin by AMPK-mediated mitochondrial dysfunction

Pair Name	Ursolic acid, Doxorubicin
Disease Info	[ICD-11: 2B91]	Colorectal cancer		Investigative
Gene Regulation	Down-regulation	Phosphorylation	AKT1	hsa207
	Up-regulation	Cleavage	CASP9	hsa842
	Down-regulation	Expression	CCN2	hsa1490
	Down-regulation	Expression	CCND1	hsa595
	Up-regulation	Expression	CDH1	hsa999
	Down-regulation	Expression	CDK4	hsa1019
	Down-regulation	Expression	CDK6	hsa1021
	Down-regulation	Phosphorylation	GSK3B	hsa2932
	Down-regulation	Expression	MMP9	hsa4318
	Up-regulation	Phosphorylation	MOB1A	hsa55233
	Up-regulation	Expression	MST1	hsa4485
	Up-regulation	Expression	MST2	hsa6788
	Down-regulation	Expression	MYC	hsa4609
	Up-regulation	Cleavage	PARP1	hsa142
	Down-regulation	Expression	PLAU	hsa5328
	Up-regulation	Expression	SAV1	hsa60485
	Up-regulation	Phosphorylation	YAP1	hsa10413
In Vitro Model	HCT 116	Colon carcinoma	Homo sapiens (Human)	CVCL_0291
	HT-29	Colon adenocarcinoma	Homo sapiens (Human)	CVCL_0320
In Vivo Model	HCT116 cells (1×10⁷) in 100 µl Matrigel were injected into the flank area of the mice.
Result	UA may be a novel anticancer strategy and could be considered for investigation as a complementary chemotherapy agent in the future.